SPINA

SPINA (Structure Parameter Inference Approach) is a method to calculate constant structure parameters of endocrine feedback control systems from serum or plasma hormone levels obtained in vivo. Equations are derived from mathematical models of the respective information processing structures.

First implementations cover thyroid homeostasis and carbohydrate metabolism. Application of SPINA on the assessment of thyrotropic feedback control is increasingly used e.g. in experimental thyroid research. Calculations are supported by software tools.

See also: G_D, G_T

Web Links

• SPINA Reference
• SPINA-Thyr (Software for calculating GT and GD)

References

1. Dietrich, J., M. Fischer, J. Jauch, E. Pantke, R. Gärtner und C. R. Pickardt (1999). "SPINA-THYR: A Novel Systems Theoretic Approach to Determine the Secretion Capacity of the Thyroid Gland." European Jounal of Internal Medicine 10, Suppl. 1 (5/1999): S34.
2. Dietrich, J. W. (2002). Der Hypophysen-Schilddrüsen-Regelkreis. Entwicklung und klinische Anwendung eines nichtlinearen Modells. Berlin, Logos-Verlag.
3. Rosolowska-Huszcz D, Kozlowska L, Rydzewski A (2005). Influence of low protein diet on nonthyroidal illness syndrome in chronic renal failure. Endocrine. 27(3):283-8
4. Dietrich, J. W., A. Stachon, B. Antic, H. H. Klein, and S. Hering (2008). "The AQUA-FONTIS Study: Protocol of a multidisciplinary, cross-sectional and prospective longitudinal study for developing standardized diagnostics and classification of non-thyroidal illness syndrome." BMC Endocrine Disorders 8 (13). PMID 18851740.