Biomedical Cybernetics

Metabolic control analysis (MCA) is a mathematical framework for describing and investigating the control of metabolic, signaling and genetic pathways including biochemical fluxes and their distribution among different enzymes. By analysing the influence of a fractional change in the activity of involved enzymes on the flux of the whole system it is a special application of sensitivity analysis.

Metabolic control analysis shares some concepts with metabolic flux analysis.

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  • Athel Cornish-Bowden, Maria Luz Cárdenas (editors). Technological and Medical Implications of Metabolic Control Analysis: Proceedings of the NATO Advanced Research Workshop, Visegard, Hungary, 10-16 April 1999 (NATO Science Partnership Sub-Series: 3: High Technology - Vol. 74). ISBN 079236189X