Biomedical Cybernetics

Homeostasis model is an approach for modelling insulin-glucose interaction. A diagnostical method derived from this model (HOMA - homeostasis model assessment) finds broad acceptance in clinical diagnostics.

Related models[]

Related and alternative approaches cover:

  • Minimal model
  • Quantitative insulin sensitivity check index (QUICKI)
  • MiMe-NoCoDI model (see also SPINA)


Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985 Jul;28(7):412-9.